Students were enquired to answer a question at school and to declare what is most important for them to succeed. Out of the many comments, one which that stood out was practice. Successful people commonly not born successful; they become successful by just hard work and commitment. This is how you can reach your goals. in the following paragraphs are one of the answer and question example that you will possibly benefit from to practice and supercharge your knowledge and also give you insights that could help you to keep up your study in school.

## Question:

In a population, if the proportion of individuals who have sickle-cell disease is 0. 50, and the population is assumed to be at Hardy-Weinberg equilibrium, what is the expected frequency of the HbS allele

## Answer:

According to **Hardy-Weinberg equilibrium**, the expected frequency of the HbS **allele** is 0.71 as the proportion of individuals who have **sickle-cell disease** is 0. 50.

**What is Hardy-Weinberg equilibrium?**

“The **Hardy-Weinberg equilibrium** is a principle stating that the genetic variation in a population will remain constant from one generation to the next in the absence of disturbing factors.”

**What are the equations to solve Hardy-Weinberg equilibrium?**

There are two equations necessary to solve a **Hardy-Weinberg Equilibrium** question:

- is the frequency of the dominant allele.
- is the frequency of the recessive allele.
- ² is the frequency of individuals with the homozygous dominant genotype.
- 2 is the frequency of individuals with the heterozygous genotype.
- ² is the frequency of individuals with the homozygous recessive genotype.

**What is an allele?**

“An **allele** is one of two or more versions of DNA sequence (a single base or a segment of bases) at a given genomic location.”

**What is sickle-cell disease?**

“**Sickle-cell disease **is** **an inherited disease in which the red blood cells have an abnormal crescent shape, block small blood vessels, and do not last as long as normal red blood cells.”

Given, the proportion of individuals who have **sickle-cell disease** is 0. 50.

∴ The homozygous recessive individuals (aa) are represented by the term in the **Hardy-Weinberg equilibrium** equation.

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#SPJ2

They will possibly hopefully help the student solve the question by implementing the questions and answer examples. You could potentially then have a discussion with your classmate and continue the school learning by studying the subject alogside each other.